Figure 3
From: Modulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?
CTLA4–Ig (cytotoxic T lymphocyte-associated antigen 4–immunoglobulin fusion protein) blocks the T cell–antigen presenting cell (APC) interaction by binding to both CD80 and CD86, thus preventing CD28 interaction. CTLA4 has a higher affinity for the B7 molecules than does CD28. TCR, T cell receptor.