Figure 2
From: Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions
Potential ligand/counter ligand interactions involved in cytokine production by macrophages. HLA-DR, human leukocyte antigen – class II, subtype DR; ICAM, intracellular adhesion molecule; LT, lymphotoxin; MMP, matrix metalloproteinase; OPN, osteoprotegrin; RNI, reactive nitrogen intermediates; TCR, T-cell receptor; TNF, tumour necrosis factor.