Fig. 6

Genetic iNOS ablation has no effect on osteoclast numbers in TNF-Tg female mice. Representative TRAP-stained slides of female TNF-Tg (a, c) and iNOS−/−× TNF-Tg mice (b, d), and their corresponding high magnification images (× 20 and × 40). Note the TRAP+ area on the surface of the condyle surface (black arrow) and in the patella (red arrows) in both the TNF-Tg and iNOS−/−× TNF-Tg mice. No differences in TRAP+ area were detected on the surface, in the patella and meniscus or the subchondral bone area (e, f, g)