Fig. 1
From: A deep learning method for predicting knee osteoarthritis radiographic progression from MRI

Overview of the image preprocessing pipeline. The raw MR image is first re-oriented so that both left and right knees are similarly oriented. Noteworthy, only the left knee image is flipped, whereas the right is maintained as is, in order to obtain uniform orientations across the dataset. The N4 bias field correction is then applied, followed by a color normalization step