Fig. 1

Differentially expressed proteins and functional analysis in each SSc subgroup. Comparison of each SSc subgroup (A–C for SSc with PAH group, SSc with ILD group, and SSc without PAH and ILD group successively) with HCs. Volcano plots on the left show differentially expressed proteins with a p-value < 0.05, fold change > 1.2 or < 0.8. The circle diagrams on the right show the top 10 terms based on a p-value < 0.05 in the GO functional analysis