Fig. 1

Peripheral blood BCR repertoire in patients undergoing rituximab treatment. Boxplots showing (A) clonal expansion: Gini index, (B) clonal diversity: Shannon index and (C) the average IGHV gene mutation load in samples obtained before (M0), and at one (M1), three (M3), six (M6) and twelve (M12) months after treatment with rituximab. Boxplots show the median, 25th and 75th interquartile, error bars show the range, and single data points are depicted in grey (*p ≤ 0.05, ***p ≤ 0.001, using one-way ANOVA)