Fig. 4

BCR repopulation is associated with improvement of disease activity shortly after and possibly with anti-drug antibodies development. A Boxplot showing the changes in DAS28-score between the month 6 and month 12 after treatment in early or late  BCR repopulating patients. Boxplots show the median and 25th and 75th interquartile, error bars show the range, and single data points are depicted in grey (** p ≤ 0.01, using unpaired t-test). B Barplot showing the correlation between anti-drugs antibodies (ADA) development and repopulation within 12 months of treatment