Fig. 4

Stratification of the genes dysregulated in active SLE patients. A-B Overview and examples of genes altered in active SLE patients. There are 1721 genes up-regulated in the active patients, of which 696 significantly decreased in remission patients and 1025 remained unchanged. There were 928 genes down-regulated in the active patients, of which 372 significantly increased in remission patients and 556 remained unchanged (C) Protein-Protein interaction network and the identification of core modules of the genes persistently up-regulated in the remission patients compared to the healthy control. D Protein-Protein interaction network and the core modules of the genes down-regulated in the remission patients comparing to the active patients