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Fig. 10 | Arthritis Research & Therapy

Fig. 10

From: Identification and verification of a novel signature that combines cuproptosis-related genes with ferroptosis-related genes in osteoarthritis using bioinformatics analysis and experimental validation

Fig. 10

Analysis of single-cell RNA sequencing data from three OA synovial samples. a UMAP plot of scRNA-seq showing unsupervised clusters colored according to putative cell types among a total of 10,194 cells in OA synovial samples. The percentages of total acquired cells were as follows: 77.7% fibroblasts, 8.8% macrophages, 3.6% dendritic cells (DCs), 3.5% endothelial cells (ECs), 3.4% smooth muscle cells (SMCs), 1.8% T cells, and 1.2% mast cells. b Heatmap depicting the expression levels of the top five marker genes among seven detected cell clusters. c, d UMAP plots and violin plots showing the expression of the selected seven hub c-FRGs and four potential biomarkers for each cell type. e Interaction net count plot of OA synovial cells. The thicker the line, the greater the number of interactions. f Interaction weight plot of synovial cells. The thicker the line, the stronger the interaction weights/strength between the two cell types. g Detailed network of cell–cell interactions among seven cell subsets

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Arthritis Research & Therapy

ISSN: 1478-6362

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