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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Identification and verification of a novel signature that combines cuproptosis-related genes with ferroptosis-related genes in osteoarthritis using bioinformatics analysis and experimental validation

Fig. 2

Extraction of particular ferroptosis-related genes (c-FRGs) and obtainment of differentially expressed c-FRGs (c-FDEGs). a, b Two-dimensional PCA cluster plot of GSE55235, GSE169077, GSE55457, and GSE55584 datasets before and after normalization. c Volcano plot of DEGs. Red spots represent upregulated genes and green spots represent downregulated genes. d Overall expression landscape of c-FRGs in osteoarthritis (OA). *P < 0.05; **P < 0.01; ***P < 0. 001. OA represents the OA group and Normal represents the normal control group. e Extraction of c-FDEGs. f Heatmap of c-FDEGs. The redder the color, the higher the expression; conversely, the bluer the color, the lower the expression

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Arthritis Research & Therapy

ISSN: 1478-6362

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