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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Identification and verification of a novel signature that combines cuproptosis-related genes with ferroptosis-related genes in osteoarthritis using bioinformatics analysis and experimental validation

Fig. 3

Functional analyses: (a) Gene Ontology (GO) enrichment analysis showed that the 40 c-FDEGs were significantly enriched in the regulation of the inflammatory response, the positive regulation of cellular catabolic process, the autophagosome membrane, the recycling endosome, and NF-κB binding. b Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these c-FDEGs were mainly involved in the IL-17 signaling pathway, NOD-like receptor signaling pathway, HIF-1 signaling pathway, and TNF signaling pathway. c Gene set enrichment analysis (GSEA) in the normal control group and (d) GSEA in the OA group based on the core set of 50 human genes suggested that the development of OA may be associated with hypoxia, MYC targets v2, the P53 pathway, the inflammatory response, TNFα signaling via NF-κB, the interferon-α response, and peroxisome

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Arthritis Research & Therapy

ISSN: 1478-6362

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