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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Identification and verification of a novel signature that combines cuproptosis-related genes with ferroptosis-related genes in osteoarthritis using bioinformatics analysis and experimental validation

Fig. 7

GSEA, GSVA, and ssGSEA results of four potential biomarkers. a–d Single-gene GSEA-KEGG pathway analysis of four potential biomarkers. We show the top six pathways with the smallest p-value. e–h High- and low-expression groups based on the expression levels of each potential biomarker combined with gene set variation analysis (GSVA). Red means the pathway is significantly upregulated, green means the pathway is significantly downregulated, and gray means the pathway is not statistically significant. i ssGSEA of OA and normal controls based on the h.all.v7.5.1.symbols.gmt gene set. *P < 0.05; **P < 0.01; ***P < 0. 001. Treat represents the OA group, and control represents the normal group. (j) Correlation of four biomarkers with 50 human symbolic gene sets from the h.all.v7.5.1.symbols.gmt gene set

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Arthritis Research & Therapy

ISSN: 1478-6362

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