Fig. 2

HDAC3 deficiency alleviated MSU crystals-induced footpad edema and ankle swelling in mice. A, B Changes in hind paw thickness and representative photographs of hind paws at 24 h time point after injection of MSU into contralateral footpads of Csf1r-HDAC3 (WT) mice and Csf1r + HDAC3 (KO) mice. C, D Changes in ankle joint thickness and representative photographs of ankle joint at 24 h time point after injection of MSU into contralateral ankle joint of Csf1r-HDAC3 (WT) mice and Csf1r + HDAC3 (KO) mice. Data were shown as mean ± SD from three independent experiments (n ≥ 9 mice per group). (*P < 0.05, by unpaired two-tailed Student’s t test)