Fig. 4

HDAC3 deficiency inhibited MSU crystals-induced TNF-α production in BMDMs. A Flow cytometry analysis of TNF-α producing BMDMs (represented by F4/80⁺TNF-α⁺) from WT and KO mice. B Percentage of TNF-α producing BMDMs from WT and KO mice at the indicated time points. Data were shown as mean ± SD from three independent experiments (n = 9 mice per group). (**P < 0.01, by unpaired two-tailed Student’s t test)