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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1

Fig. 5

Improvement in dABp is differential among the cartilage structural response variables and is accompanied with flSIRT1 increase. Joint distraction cohort (n = 33) were stratified for the number of patients showing 2-year improvement post-distraction for 4 cartilage structural variables (Mean MAC JSW; Min JSW; MAC ThCtAB and dABp), reflecting a low structural response (0/4) vs. a high structural response (4/4). (A) The percent within a given category (i.e. 1/4, 2/4 or 3/4) that shows a change in one of the four cartilage-related variables. (B) Association of dABp with flSIRT1 (ρ= -0.196, p = 0.133); and (C) NT/CT SIRT1 (ρ = 0.22, p = 0.2115), at baseline. Two-year change in dABp compared to (D) flSIRT1 (ρ= -0.303, p = 0.0817); or (E) NT/CT SIRT1 (ρ= -0.330, p = 0.056). Statistical significance was determined using a two-tailed Spearman r correlation, assuming significance at p < 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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