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Table 1 Knee joint distraction patients baseline characteristics and two-year changes

From: Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1

Parameter

Baseline

Two-year change

Age, years

54.1 ± 6.6

 

Male gender, n (%)

22 (61)

BMI, kg/m2

27.1 ± 13.4

Kellgren-Lawrence grade, n (%)

 

- Grade 0

0 (0)

 

- Grade 1

5 (14)

 

- Grade 2

5 (14)

 

- Grade 3

15 (42)

 

- Grade 4

11 (31)

 

Total KOOS, 0-100

47.9 (28.2–57.0)

25.5 (12.4–38.1)

VAS pain, 10 − 0

6.3 (3.7–7.5)

-2.9 (-4.8 – -1.1)

MAC ThCtAB, mm

1.9 (1.4–2.6)

0.0 (-0.1–0.3)

MAC dABp, %

23.9 (11.8–38.8)

-0.8 (-8.4 – -1.4)

MAC mean JSW, mm

1.8 (0.6–2.9)

0.3 (-0.1–1.1)

Minimum JSW, mm

0.0 (0.0–0.5)

0.4 (0.0–1.0)

MAC subchondral bone density, mm Al eq

37.1 (35.0–39.1)

1.6 (-0.4–4.8)

Osteophyte area, mm2

37.5 (20.1–56.0)

5.7 (1.2–13.5)

NT/CT, ratio

7.0 (3.5–11.3)

-0.4 (-1.3–0.5)

flSIRT1, µg/mL

9.8 (2.0–17.2)

-0.6 (-9.3–5.9)

Z-index PIIANP/CTX-II

0.1 (-0.7–0.9)

0.5 (0.0–1.5)

  1. Mean ± standard deviation, median (Q1 – Q3), or n (%) are presented. BMI: body mass index; KOOS: knee injury and osteoarthritis outcome score; VAS: visual analogue scale; MAC: most affected compartment; ThCtAB: mean cartilage thickness over the total subchondral bone area; dABp: percentage of denuded subchondral bone area; JSW: joint space width; mm Al eq: mm Aluminum equivalent (in reference to an aluminum step wedge); NT/CT: N-terminal/C-terminal; flSIRT1: full-length sirtuin-1; PIIANP: N-propeptide of collagen IIA; CTX-II: C-terminal cross-linked telopeptides of type II collagen
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Arthritis Research & Therapy

ISSN: 1478-6362

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