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Table 2 Baseline and 2-year change correlations for serum NT/CT SIRT1 and clinical or structural markers

From: Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1

Parameter

ρ

P-value

Baseline

KOOS

−0.058

0.736

VAS pain

0.105

0.541

MAC ThCtAB

−0.172

0.337

MAC dABp

0.220

0.211

MAC JSW

−0.242

0.155

Min JSW

−0.214

0.210

MAC bone density

−0.126

0.464

Osteophytes

0.350

0.036

Z PIIANP/CTX-II

−0.363

0.041

Two-year changes

KOOS

0.210

0.226

VAS pain

−0.182

0.288

MAC ThCtAB

0.201

0.262

MAC dABp

−0.331

0.056

MAC JSW

0.005

0.976

Min JSW

0.030

0.862

MAC bone density

0.086

0.616

Osteophytes

−0.010

0.956

Z PIIANP/CTX-II

0.321

0.078

  1. Spearman correlation coefficients and p-values are presented. NT/CT SIRT1: N-terminal/C-terminal sirtuin-1; BMI: body mass index; KOOS: knee injury and osteoarthritis outcome score; VAS: visual analogue scale; MAC: most affected compartment; ThCtAB: mean cartilage thickness over the total subchondral bone area; dABp: percentage of denuded subchondral bone area; JSW: joint space width; PIIANP: N-propeptide of collagen IIA; CTX-II: C-terminal cross-linked telopeptides of type II collagen
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Arthritis Research & Therapy

ISSN: 1478-6362

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