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Table 3 Baseline and 2-year change correlations for serum flSIRT1 and clinical or structural markers

From: Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1

Parameter

ρ

P-value

Baseline

KOOS

0.155

0.368

VAS pain

−0.069

0.690

MAC ThCtAB

0.062

0.731

MAC dABp

−0.196

0.267

MAC JSW

−0.001

0.994

Min JSW

0.089

0.607

MAC bone density

−0.138

0.421

Osteophytes

−0.176

0.305

Z PIIANP/CTX-II

0.111

0.547

Two-year changes

KOOS

0.222

0.200

VAS pain

−0.002

0.989

MAC ThCtAB

0.199

0.268

MAC dABp

−0.303

0.082

MAC JSW

0.102

0.554

Min JSW

0.011

0.948

MAC bone density

0.008

0.962

Osteophytes

−0.036

0.837

Z PIIANP/CTX-II

−0.118

0.526

  1. Spearman correlation coefficients and p-values are presented. flSIRT1: full-length sirtuin-1; BMI: body mass index; KOOS: knee injury and osteoarthritis outcome score; VAS: visual analogue scale; MAC: most affected compartment; ThCtAB: mean cartilage thickness over the total subchondral bone area; dABp: percentage of denuded subchondral bone area; JSW: joint space width; NT/CT: N-terminal/C-terminal; flSIRT1: full-length sirtuin-1; PIIANP: N-propeptide of collagen IIA; CTX-II: C-terminal cross-linked telopeptides of type II collagen
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Arthritis Research & Therapy

ISSN: 1478-6362

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