Fig. 1
From: Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
OARSI scoring of stifles from UMHET3 mouse model. A UM-HET3 is a genetically diverse mouse model, generated via 4way cross of (BALB/cByJ × C57BL/6J) F1 mothers and (C3H/HeJ × DBA/2J) F1 fathers. Each of the offspring is genetically unique but shares 50% of its genetic material with every other UM-HET3 mouse. B Shown are representative knee joint samples that were processed for safranin-O-red, or (C) H&E staining of the synovial membrane that were categorized based on the OARSI scoring system [15,16,17]