Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice

Poudel, Sher Bahadur; Ruff, Ryan R.; Yildirim, Gozde; Miller, Richard A.; Harrison, David E.; Strong, Randy; Kirsch, Thorsten; Yakar, Shoshana

doi:10.1186/s13075-024-03349-y

Arthritis Research & Therapy

Table 1 SCB morphology of male and female mice determined by micro-CT. Bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), and bone mineral density (BMD)

From: Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice

								Main effects			Interactions
	M CTL (n=47)	M MB (n=22)	M MitoQ (n=22)	F CTL (n=45)	F MB (n=24)	F MitoQ (n=22)		MB	MQ	M (vs F)	MB*M	MQ*M
Distal Femur Subchondral Bone
BV/TV, %	21.7618± 0.7489	20.9130± 1.0306	21.8811± 1.5200	17.6319± 0.6837	17.5472± 0.7915	17.7906± 0.9468	B	-0.526	0.2029	3.924	-0.76258	-0.03787
							SE	1.043	1.0497	0.7396	1.79945	1.85574
							p	0.615	0.847	3.39E-07	0.67225	0.983741
Tb.Th, mm	0.0688± 0.0012	0.0678± 0.0020	0.0687± 0.0020	0.0749± 0.0016	0.0759± 0.0022	0.0789± 0.0023	B	-0.000145	0.0019519	-0.0075682	-0.0019332	-0.0041596
							SE	0.00207	0.0020854	0.0014693	0.0035634	0.0036748
							p	0.944	0.351	6.97E-07	0.58817	0.25924
Tb.Sp, mm	0.2532± 0.0057	0.2539± 0.0065	0.2512± 0.0109	0.3296± 0.0065	0.3243± 0.0061	0.3336± 0.0096	B	-0.0022881	0.0007131	-0.0762672	0.0060545	-0.0059524
							SE	0.0084013	0.0084558	0.0059576	0.0144828	0.0149359
							p	0.786	0.933	2.00E-16	0.676	0.691
Tb.N, 1/mm	3.1403± 0.0790	3.0609± 0.0990	3.1812± 0.1763	2.3486± 0.0742	2.3010± 0.0653	2.2506± 0.1004	B	-0.062927	-0.024334	0.816088	-0.03187	0.138898
							SE	0.110956	0.111676	0.078683	0.191178	0.197159
							p	0.571	0.828	<2e-16	0.868	0.482
BMD, g/cc	0.2480± 0.0072	0.2344± 0.0090	0.2530± 0.0137	0.2208± 0.0072	0.2114± 0.0087	0.2307± 0.0097	B	-0.00532	0.001547	0.025015	-0.004436	-0.00509
							SE	0.010117	0.010183	0.007175	0.017461	0.018007
							p	0.599648	0.879432	0.000619	0.79975	0.77775
Proximal Tibia Subchondral Bone
BV/TV, %	20.3482± 0.6811	20.6231± 1.2275	18.6409± 1.0443	17.0072± 0.7781	16.7714± 1.0041	15.9309± 0.7885	B	-1.1174	-0.4082	3.3361	0.46492	-0.67686
							SE	1.0344	1.0038	0.7198	1.76073	1.77353
							p	0.2815	0.6848	7.09E-06	0.79207	0.70321
Tb.Th, mm	0.0651± 0.0010	0.0671± 0.0015	0.0642± 0.0013	0.0724± 0.0014	0.0705± 0.0018	0.0709± 0.0018	B	-0.001612	0.0002615	-0.006148	3.83E-03	5.71E-04
							SE	0.0016909	0.001641	0.0011768	2.87E-03	2.89E-03
							p	0.3418	0.8736	5.06E-07	0.1828	0.8434
Tb.Sp, mm	0.2135± 0.0030	0.2180± 0.0063	0.2314± 0.0057	0.2601± 0.0038	0.2558± 0.0063	0.2674± 0.0056	B	0.00244	0.010634	-0.041754	0.008938	0.010821
							SE	0.005548	0.005384	0.003861	0.009407	0.009475
							p	0.6607	0.0499	<2e-16	0.343	0.255
Tb.N, 1/mm	3.1047± 0.0739	3.0392± 0.1355	2.8963± 0.1369	2.3249± 0.0827	2.3618± 0.1231	2.2370± 0.0891	B	-0.10127	-0.07336	0.72489	-0.10591	-0.12402
							SE	0.11812	0.11463	0.0822	0.20097	0.20244
							p	0.392	0.523	1.34E-15	0.599	0.541
BMD, g/cc	0.2389± 0.0070	0.2365± 0.0105	0.2302± 0.0103	0.2175± 0.0075	0.2080± 0.0105	0.2085± 0.0082	B	-0.010901	-0.004595	0.0234	6.80E-03	6.80E-03
							SE	0.01027	0.009966	0.007147	1.75E-02	1.76E-02
							p	0.28999	0.64532	0.00128	0.698	0.9957
Tibia Subchondral Plate
SCB plate Th, mm	0.1080± 0.0036	0.0918± 0.0055	0.1027± 0.0044	0.1009± 0.0032	0.0890± 0.0061	0.1059± 0.0044	B	-0.007202	-0.005887	0.003244	-0.0037615	-0.0097749
							SE	0.004989	0.004816	0.003462	0.0084504	0.008512
							p	0.1507	0.2232	0.3501	0.6568	0.2524
SCB plate BMD, g/cc	0.8638± 0.0147	0.8529± 0.0168	0.9381± 0.0058	0.8914± 0.0167	0.8690± 0.0190	0.9620± 0.0085	B	0.02725	0.03507	-0.02518	0.01436	0.00654
							SE	0.01429	0.01789	0.01727	0.0304	0.03062
							p	0.1295	0.0438	0.0441	0.6374	0.8312

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