Fig. 2

Proportions of Patients Achieving CDAI, DAS28(CRP) Disease Activity States and Boolean Remission Through 5 Years (AO). AO, as observed; CDAI, Clinical Disease Activity Index; DAS28(CRP), 28-joint Disease Activity Score based on C-reactive protein; LDA, low disease activity; mono, monotherapy; MTX, methotrexate; QD, once daily; UPA, upadacitinib. ^aPatients in the UPA 30 mg treatment group were later switched to the approved UPA 15 dose mg per protocol amendment. The switch occurred at different visits across the patient population, with the earliest switch occurring at the week 108 visit. Thresholds for CDAI were ≤ 2.8 for remission and ≤ 10 for LDA