Fig. 6

Radiographic Progression Through 5 Years (AO). AO, as observed; BL, baseline; mono, monotherapy; mTSS, modified Total Sharp Score; MTX, methotrexate; QD, once daily; UPA, upadacitinib. ^aPatients in the UPA 30 mg treatment group were later switched to the approved UPA 15 mg dose per protocol amendment. The switch occurred at different visits across the patient population, with the earliest switch occurring at the week 108 visit. Patients were required to have radiographic images at both week 192 and week 260 for inclusion in these analyses. Error bars represent the 95% confidence interval