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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection – a novel disease-modifying osteoarthritis drug

Fig. 1

KBP-336 decreases mechanical allodynia in the metabolic OA rat model. (A) The mean percentage change of 50% paw withdrawal threshold (PWT) from baseline PWT of female SD rats on a high-fat diet that received sham surgery on vehicle treatment (Sham + Vehicle), meniscectomy on vehicle treatment (MNX + Vehicle), or meniscectomy on KBP-336 treatment (MNX + KBP-336 4.5 nmol/Kg/72 h) groups n = 8, 10, and 10 rats per group, respectively. (B) The net area under the curve (AUC) derived from plot (A). (C) The mean OA score for the medial tibial cartilage. Error bars indicate the standard error of the mean. Two-way ANOVA with Dunnett’s adjustment for multiple comparisons was used for (A). One-way ANOVA test with Dunnett’s adjustment for multiple comparisons was used for (B). Kruskal-Wallis test with Dunn’s adjustment for multiple comparison was used for (C). Statistical significance is indicated by *P < 0.05, **P < 0.01, and ***P < 0.001 vs. MNX + Vehicle (A)

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Arthritis Research & Therapy

ISSN: 1478-6362

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