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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection – a novel disease-modifying osteoarthritis drug

Fig. 2

KBP-336 lowers body weight and fat depots. (A) The mean percentage change of body weights of female SD rats on a high-fat diet that received sham surgery on vehicle treatment (Sham + Vehicle), meniscectomy on vehicle treatment (MNX + Vehicle), or meniscectomy on KBP-336 treatment (MNX + KBP-336 4.5 nmol/kg/72 h) groups n = 8, 10, and 10 rats per group, respectively. (B) The mean weight of inguinal adipose tissue at the end of the study. (C) The mean weight of perirenal adipose tissue at the end of the study. Error bars indicate the standard error of the mean. One-way ANOVA test with Dunnett’s adjustment for multiple comparisons was used for analysis. Statistical significance is shown by *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001

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Arthritis Research & Therapy

ISSN: 1478-6362

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