Table 1 Treatment outcomes at 6 months by disease activity
Total (N = 1828) | Disease activity at 6 months | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Remission/LDA (CDAI ≤ 10, N = 1446) | MDA/HDA (CDAI > 10, N = 382) | |||||||||
Mean | SE | Median | Mean | SE | Median | Mean | SE | Median | ||
CDAI at 6 months | 6.50 | 0.16 | 4.7 | 3.74 | 0.08 | 3.3 | 17.14 | 0.38 | 14.7 | |
SDAI at 6 months | 6.79 | 0.17 | 4.9 | 3.97 | 0.08 | 3.54 | 17.78 | 0.41 | 14.985 | |
DAS28-ESR at 6 months | 2.90 | 0.03 | 2.76 | 2.50 | 0.02 | 2.45 | 4.47 | 0.05 | 4.43 | |
HAQ-DI at 6 months | 0.78 | 0.02 | 0.625 | 0.64 | 0.02 | 0.375 | 1.33 | 0.04 | 1.25 | |
Pain VAS at 6 months | 28.00 | 0.57 | 21 | 21.18 | 0.52 | 15 | 53.99 | 1.19 | 57 | |
Change in clinical parameters at 6 months | Δ CDAI | -18.33 | 0.29 | -17 | -19.80 | 0.31 | -18 | -12.66 | 0.67 | -11.3 |
Δ SDAI | -19.99 | 0.03 | -18.34 | -21.54 | 0.35 | -19.38 | -13.96 | 0.74 | -12.51 | |
Δ DAS28-ESR | -2.46 | 0.03 | -2.44 | -2.77 | 0.04 | -2.72 | -1.30 | 0.07 | -1.26 | |
Δ HAQ | -0.40 | 0.02 | -0.25 | -0.46 | 0.02 | -0.25 | -0.19 | 0.03 | -0.125 | |
Δ Pain VAS | -23.70 | 0.67 | -20 | -27.63 | 0.73 | -24 | -8.67 | 1.35 | -7.5 | |
N | % | N | % | N | % | |||||
HAQ-DI improvement* | 993 | 54.3 | 839 | 58.0 | 154 | 40.3 | ||||
HAQ-DI at 6 months ≤ 0.5 | 783 | 42.8 | 732 | 50.7 | 50 | 13.1 | ||||
Pain VAS reduction at 6month** | 490 | 26.8 | 454 | 31.4 | 36 | 9.4 | ||||