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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: TGFβ signaling pathway is altered by HLA-B27 expression, resulting in pathogenic consequences relevant for spondyloarthritis

Fig. 3

BMP/TGFβ pathway receptors expression in Tn and Teff from B27 and NTG rats. The mRNA expression of TGFβ and activin receptor genes was assessed by RT-qPCR in ex-vivo sorted Tn and Teff from NTG (grey bar – white dots) and B27 (red bar – red dots) adult rat mLNs. Scattered dot plot with bars represents the mean of mRNA relative expression in arbitrary units (A.U) out of 8 to 11 experiments. Differences between NTG and B27 expression levels for each receptor were tested by unpaired t-tests with Welch’s correction (**: p < 0.01). Error bars show SEM. On the first row Acvr1, Bmpr1a, Acvr1b, Tgfbr1 and Acvr1c genes coding for ALK2, ALK3, ALK4, ALK5 and ALK7 BMPR1s respectively. On the second row Acvr2a, Acvr2b, Bmpr2 and Tgfbr2 represent type 2 BMP receptor genes

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Arthritis Research & Therapy

ISSN: 1478-6362

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