Fig. 2

Prevalence of D2T-RA patients among refractory RA patients in the 12 months of observation. Prevalence of D2T-RA patients among refractory RA patients in the 12 months of observation. For each time point, the overall frequency (percentage) of pD2T-RA (red), eD2T-RA (yellow), and non-D2T-RA (green) is reported. Noteworthy, 41.3% of refractory patients were never D2T-RA (grey area at the bottom). Abbreviations. RA: Rheumatoid Arthritis; pD2T-RA: persistent difficult-to-treat; eD2T-RA: episodic difficult-to-treat; D2T-RA: difficult-to-treat