Fig. 4

A Rate of criteria fulfillment at each timepoint and (B) between pD2T-RA and eD2T-RA. A Rate of criteria fulfillment at each timepoint, either including all events (overall) or the rate of definition fulfillment for a single criterion (alone). B Median rate of criteria fulfillment between pD2T-RA and eD2T-RA (excluding patients that never fulfilled the D2T-RA definition) along the 12-month observation period. Abbreviations. SDAI: Simplified Disease Activity Index; CRP: C-reactive protein; pD2T-RA: persistent difficult-to-treat