Table 1 Baseline clinical characteristics of 1,201 participants with/without elevated serum IgG4 level
From: Factors related to elevated serum immunoglobulin G4 (IgG4) levels in a Japanese general population
|  | All (n = 1,201) | IgG4 elevation (+) (n = 42) | IgG4 elevation (-) (n = 1,159) | P-values |
|---|---|---|---|---|
Age (years) | 62 ± 11 | 66 ± 11 b | 62 ± 11 | 0.026 |
Gender (male, %) | 46 | 69 b | 46 | 0.004 |
BMI (kg/m2) | 23.3 ± 3.3 | 23.4 ± 3.4 | 23.3 ± 3.3 | 0.771 |
Systolic BP (mmHg) | 138 ± 19 | 135 ± 20 | 138 ± 19 | 0.569 |
Diastolic BP (mmHg) | 80 ± 12 | 78 ± 11 | 80 ± 12 | 0.187 |
Smoking history (+, %) | 46 | 60 | 46 | 0.085 |
Allergic disease (+, %) | 13 | 18 | 13 | 0.248 |
History of Malignancy (+, %) | 7 | 6 | 7 | 0.999 |
Fraction of Eosinophil (%) | 2.7 ± 2.1 | 3.0 ± 2.4 | 2.7 ± 2.0 | 0.539 |
Serum IgE level (IU/mL) | 225 ± 593 (n = 1,001) | 366 ± 439 b (n = 39) | 219 ± 598 (n = 962) | < 0.001 |
Serum IgG level (mg/dL) | 1,319 ± 273 (n = 1,136) | 1,564 ± 349 b (n = 40) | 1,310 ± 266 (n = 1,096) | < 0.001 |
Serum IgG4 level (mg/dL) | 44 ± 36 | 172 ± 39 b | 40 ± 26 | < 0.001 |
Serum CH50 level (U/mL) | 38 ± 9 (n = 1,126) | 38 ± 8 (n = 40) | 38 ± 9 (n = 1,086) | 0.984 |
Serum CRP level (mg/dL) | 0.12 ± 0.45 | 0.16 ± 0.32 | 0.12 ± 0.45 | 0.248 |
ANA positivity (+, %) | 7.4 (n = 975) | 15.2 (n = 33) | 7.1 (n = 942) | 0.089 |
RF positivity (+, %) | 8.6 (n = 975) | 15.2 (n = 33) | 8.4 (n = 942) | 0.196 |
Serum creatinine level (mg/dL)a | 0.79 ± 0.46 | 0.82 ± 0.27 | 0.79 ± 0.47 | 0.849 |
eGFR-creatinine (mL/min/1.73m2) | 71 ± 14 | 71 ± 16 | 71 ± 14 | 0.924 |
Serum cystatin-C level (mg/dL) | 0.91 ± 0.41 (n = 1,057) | 0.99 ± 0.24 b (n = 35) | 0.91 ± 0.41 (n = 1,022) | 0.015 |
eGFR-cystatin-C (mL/min/1.73m2) | 83 ± 19 (n = 1,057) | 76 ± 20 b (n = 35) | 83 ± 19 (n = 1,022) | 0.045 |
Serum LDL-cholesterol level (mg/dL) | 130 ± 35 | 132 ± 32 | 130 ± 36 | 0.736 |
Serum HDL-cholesterol level (mg/dL) | 65 ± 17 | 59 ± 13 b | 66 ± 17 | 0.018 |
Serum triglyceride level (mg/dL) | 117 ± 81 | 140 ± 189 | 116 ± 74 | 0.348 |
Serum uric acid level (mg/dL) | 5.1 ± 1.4 | 5.4 ± 1.5 | 5.1 ± 1.4 | 0.135 |
HbA1c level (%) | 5.9 ± 0.6 | 6.2 ± 1.0 | 5.9 ± 0.6 | 0.176 |
Protein intake (%) | 15.2 ± 3.2 (n = 938) | 14.2 ± 3.1 (n = 36) | 15.2 ± 3.2 (n = 902) | 0.116 |
Lipid intake (%) | 24.7 ± 6.1 (n = 938) | 21.8 ± 5.9 b (n = 36) | 24.9 ± 6.1 (n = 902) | 0.007 |
Carbohydrate intake (%) | 54.0 ± 8.7 (n = 938) | 57.1 ± 9.1 (n = 36) | 53.9 ± 8.7 (n = 902) | 0.085 |
Polyunsaturated fatty acids intake (%) | 6.1 ± 1.5 (n = 938) | 5.4 ± 1.4b (n = 36) | 6.2 ± 1.5 (n = 902) | 0.011 |
Saturated fatty acids intake (%) | 6.5 ± 2.0 (n = 938) | 5.8 ± 2.0b (n = 36) | 6.6 ± 2.0 (n = 902) | 0.044 |