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Table 3 Correlation matrix for markers of disease activity with pain severity and pain sensitivity

From: Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain

 

Inflammation marker

DAS28-ESR

(0-9.4)

DAS28-CRP

(0-9.4)

US-Combined (0–48)

ESR

(mm/hr)

CRP (mg/l)

TJC

(0–28)

SJC

(0–28)

VAS-GH

(0-100)

US-SH

(0–48)

US-PD

(0–48)

 

Clinical

Pain

Severity

Summated Pain Score (0–30)

0.43***

0.42***

0.18

0.43***

0.43***

0.14

0.29**

0.55***

0.20*

0.27**

 

Pain Now (0–10)

0.44***

0.48***

0.11

0.33***

0.33***

0.27*

0.31**

0.65***

0.11

0.20

 

Pain Strongest (0–10)

0.42***

0.34**

0.28*

0.49***

0.49***

0.06

0.23*

0.36***

0.17

0.28**

 

Pain Average (0–10)

0.29**

0.29**

0.12

0.35***

0.35***

0.06

0.20*

0.45***

0.26*

0.28**

 

Pain Sensitivity

PPTTibialis Anterior (kPa)

-0.35**

-0.28**

-0.01

-0.22*

-0.18

-0.26*

-0.21*

-0.25*

0.03

-0.08

 

PPTBrachioradialis (kPa)

-0.31**

-0.21*

0.07

-0.26*

-0.19

-0.18

-0.22*

-0.15

0.12

-0.01

 

TS (0–10)

0.07

0.09

0.12

-0.01

0.09

0.02

0.02

0.21*

0.08

0.08

 

CPM (kPa)

-0.26*

-0.19

-0.06

-0.19

-0.28*

-0.05

-0.28**

-0.07

0.01

-0.15

 

TSD (-28 to 28)

0.47***

0.59***

0.01

-0.10

0.05

0.88***

0.18

0.38***

0.02

-0.05

 
  1. Data are Spearman’s correlation coefficients. CRP: C-Reactive Protein, Cor: Pearson or Spearman Correlation, CPM: Conditioned Pain Modulation, DAS28: Disease Activity Score – 28 Joints, ESR: Erythrocyte Sedimentation Rate, kPa: kiloPascals, mm/hr: millimetres per hour, mg/l: milligrams per litre, PPT: Pain Pressure Detection Threshold, SJC: Swollen Joints Count, TJC: Tender Joints Count, TS: Temporal Summation, TSD: Tender-Swollen Joint Count Difference, QST: Quantitative Sensory Testing, US-Combined: Ultrasound – Combined EULAR-OMERACT Score, US-PD: Ultrasound – Power Doppler, US-SH: Ultrasound – Synovial Hypertrophy, VAS-GH: Visual Analogue Scale – Global Health
  2. All p-values have been corrected for multiple comparisons (Benjamini-Hochberg)
  3. Values in bold indicate statistical significance. * ≤0.05, ** <0.01, ***<0.001