Increased serum level of IL-6 predicts poor prognosis in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease

Table 3 The discretized serum level of IL-6 and lymphocytes to predict 6-month death and RP-ILD in patients with anti-MDA5-positive DM based on multivariate Cox regression analysis

Variables	Death		RP-ILD
	HR (95%CI)	P-value	HR (95%CI)	P-value
Lymphocytes (× 10⁹/L)
>1.0	ref		ref
0.5–1.0	6.307 (1.494–26.620)	0.012	5.296 (2.083–13.464)	< 0.001
<0.5	8.717 (2.040–37.254)	0.004	6.565 (2.499–17.248)	< 0.001
IL-6 (pg/mL)
<13.41	ref		ref
≥13.41	3.615 (2.059–6.350)	< 0.001	2.882 (1.836–4.525)	< 0.001
Age on onset (years, per SD increase)	1.555 (1.201–2.015)	< 0.001
LDH (U/L, per SD increase)	1.317 (1.085–1.598)	0.005

Abbreviations: LDH lactate dehydrogenase, RP-ILD rapidly progressive interstitial lung disease

ISSN: 1478-6362