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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Integrated multi-omics revealed that dysregulated lipid metabolism played an important role in RA patients with metabolic diseases

Fig. 3

Down-regulation of unsaturated fatty acids (UFAs) in RA_MD patients. Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) displayed the differential metabolites of anionic (A) and cationic (B) modes between RA_MD and RA. (C) Volcano plot showed that the differentially expressed metabolites between RA and RA_MD. (D) The KEGG enrichment analysis of 42 significant metabolites between RA_MD and RA. (E-H) The relative abundance of galactonic acid, 20-HETE, 9-OxoDE and all cis-(6, 9, 12)-linolenic acid among control, RA and RA_MD. (I) Spearman’s correlation heatmap of differential metabolites and clinical characteristics

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Arthritis Research & Therapy

ISSN: 1478-6362

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