Table 1 Characteristics of the enrolled population arrayed according to the D2T criteria
|  | Total (n = 458) | D2T-RA (n = 71) | Non D2T-RA (n = 387) | P-value |
|---|---|---|---|---|
Male gender [n (%)] | 106 (23.14) | 16 (22.53) | 90 (23.26) | 0.895 |
Age (years) [median (IQR)] | 62 (52–73) | 62 (58- 65) | 62 (60- 63) | 0.980 |
Disease duration (years) [median (IQR)] | 12 (10–14) | 15 (13–17) | 10 (9–11) |  < 0.0001 |
RF pos [n (%)] | 277 (60.48) | 43 (61.43) | 234 (61.74) | 0.961 |
ACPA pos [n (%)] | 278 (60.70) | 48 (68.57) | 230 (60.85) | 0.223 |
Erosive disease [n (%)] | 164 (35.81) | 41 (58.57) | 123 (32.28) |  < 0.0001 |
Erosions at baseline [n (%)] | 43 (9.39) | 12 (23.53) | 31 (10.62) | 0.012 |
Surgery for RA [n (%)] | 34 (7.42) | 12 (16.90) | 22 (5.70) | 0.002 |
Poor prognostic factors [n (%)] | 249 (54.37) | 54 (76.06) | 195 (51.05) |  < 0.0001 |
Previous or current Smokers [n (%)] | 140 (30.57) | 14 (19.72) | 126 (32.56) | 0.237 |
Power Doppler pos [n (%)] | 83 (18.12) | 15 (31.25) | 68 (31.63) | 0.959 |
Morning Stiffness > 1 h [n (%)] | 48 (10.48) | 11 (15.49) | 37 (9.56) | 0.138 |
CRP > 0.5 mg/dL at diagnosis [n (%)] | 119 (25.98) | 10 (41.67) | 109 (58.92) | 0.113 |
CDAI at last follow up (mean + SD) | 8.8 (6.5–9.5) | 15.7 (12.9–18.5) | 7.5 (6.5–8.5) |  < 0.0001 |
CRP > 0.5 mg/dL at last follow up [n (%)] | 35 (7.64) | 6 (10.17) | 29 (9.29) | 0.833 |
csDMARDs [n (%)] | 258 (56.33) | 30 (42.25) | 228 (58.91) | 0.009 |
bDMARDs [n (%)] | 174 (38.00) | 30 (42.25) | 144 (37.80) | 0.478 |
tsDMARDs [n (%)] | 151 (32.97) | 40 (56.34) | 111 (29.37) |  < 0.0001 |
Glucocorticoids [n (%)] | 110 (24.02) | 20 (28.17) | 90 (23.5) | 0.399 |