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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls

Fig. 4

IL-1β and IL-6 production after 24 h stimulation of PBMCs in vitro. A Freshly isolated PBMCs originating from healthy controls (n = 316) stimulated with C16/MSU crystal 300ug/ml for 24 h. After 24 h the supernatants were collected and IL-1β and IL-6 (R&D Systems, Minneapolis) was measured. B Freshly isolated PBMCs originating from healthy controls (n = 316) stimulated with LPS 100ng for 24 h. After 24 h the supernatants were collected and IL-1β and IL-6 was measured. C Freshly isolated PBMCs originating from healthy controls (n = 316) stimulated with Candida albicans conidia for 24 h. After 24 h the supernatants were collected and IL-1β and IL-6 was measured. The lowest range of detection was 78 pg/ml for IL-1β; 312 pg/ml for IL-6. Graphs depict means with SD. Kruskal-Wallis and post-hoc analysis p < 0,05

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Arthritis Research & Therapy

ISSN: 1478-6362

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