Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement

Liu, Lu; de Leeuw, Karina; van Goor, Harry; Doornbos-van der Meer, Berber; Arends, Suzanne; Westra, Johanna

doi:10.1186/s13075-024-03454-y

Table 2 Logistic regression with thiols as dependent variable with demographic, clinical and laboratory parameters

From: Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement

	R²	Univariable analysis		Multivariable analysis
	R²	B (95% CI)	p-value	B (95% CI)	p-value
Gender female (%)	0.019	1.173 (-0.612 to 2.958)	0.195		a
Age (year)	0.239	-0.105 (-0.145 to -0.066)	0.000		b
Disease duration (year)*	0.133	-0.106 (-0.165 to -0.047)	0.001	-0.082 (-0.144 to -0.020)	0.010
LN (yes/no)	0.038	-1.333 (-2.743 to 0.077)	0.064		a
SLEDAI (score)	0.011	0.229 (-0.231 to 0.689)	0.326		a
BMI (kg/m2)*	0.09	-0.169 (-0.285 to -0.052)	0.005		c
Prednisolone (yes/no)	0.041	-1.283 (-2.575 to 0.009)	0.052		a
Smoking (yes/no)**	0.002	0.302 (-1.178 to 1.781)	0.686		a
Alcohol (yes/no)**	0.004	0.423 (-1.181 to 2.028)	0.601		a
Systolic blood pressure (mmHg)	0.071	-0.053 (-0.093 to -0.013)	0.010		c
Diastolic blood pressure (mmHg)	0.007	-0.029 (-0.101 to 0.042)	0.414		a
NET (Au/ml)	0.067	-0.048 (-0.086 to -0.010)	0.013	-0.054 (-0.086 to -0.021)	0.002
Proteinuria (yes/no)*	0.059	-2.315 (-4.256 to -0.373)	0.020		c
Thrombocytes (10^9/L)*	0.004	0.003 (-0.006 to 0.012)	0.533		a
Hemoglobin (mmol/L)	0.042	0.726 (-0.001 to 1.452)	0.050		c
Lymphocytes total amount (10^9/L)	0.017	0.667 (-0.410 to 1.743)	0.222		a
Neutrophils total amount (10^9/L)	0.050	-0.285 (-0.546 to -0.024)	0.033		c
Leukocytes (10^9/L)	0.032	-0.212 (-0.457 to 0.033)	0.089		a
C-reactive protein (mg/L)*	0.067	-0.098 (-0.176 to -0.021)	0.014		c
eGFR (ml/min)	0.307	0.072 (0.049 to 0.095)	0.000	0.059 (0.033 to 0.085)	< 0.001
Serum creatinine (µmol/L)	0.242	-0.054 (-0.074 to -0.034)	0.000		b
Albumin (g/L)**	0.057	0.194 (0.017 to 0.371)	0.033		c
Cholesterol (mmol/L)*	0.009	-0.325 (-1.028 to 0.377)	0.360		a
Triglyceride (mmol/L)¶	0.010	-0.384 (-1.529 to 0.761)	0.503		a
LDL-C (mmol/L)*	0.003	-0.230 (-1.072 to 0.612)	0.588		a
HDL-C (mmol/L)*	0.002	0.303 (-1.004 to 1.609)	0.647		a
ALAT (U/L)	0.005	0.016 (-0.029 to 0.062)	0.483		a
anti-dsDNA titer (IU/ml)	0.002	0.008 (-0.029 to 0.045)	0.672		a
Complement 3 (g/L)	0.107	-4.871 (-7.823 to -1.919)	0.001		c
Complement 4 (g/L)	0.032	-6.351 (-13.658 to 0.957)	0.088		a

Abbreviations: LN Lupus nephritis, SLEDAI the Systemic Lupus Erythematosus Disease Activity Index, BMI Body mass index, NET Neutrophil extracellular trap, eGFR estimated glomerular filtration rate, LDL-C Low-density lipoprotein-cholesterol, HDL-C High-density lipoprotein-cholesterol, ALAT Alanine aminotransferase, anti-dsDNA anti-double stranded DNA
a. The variable was not included in multivariable regression analysis due to a p-value of ≥ 0.050 in univariable regression analysis
b. Age and serum creatinine were not tested in multivariable regression analysis because disease duration and eGFR were included
c. Variables were not selected during multivariable regression analysis (p ≥ 0.050)
Missing data * ≤ 7%, **7–17%, ¶ > 17%; B, coefficient

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