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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage

Fig. 5

Decreased MHCII + macrophages, but no change in CD163 + macrophages in the DRG after systemic macrophage depletion in both sexes. A Frequency of total F4/80 + macrophages, (B) F4/80 + MHCII+, (C) F4/80 + CD163+, (D) CD163-MHCII-, (E) CD163-MHCII+, (F) CD163 + MHCII+, (G) CD163 + MHCII- macrophage populations in the DRG in male MaFIA mice at 8 weeks after DMM surgery for Vehicle (blue, n = 5) or AP20187 (red, n = 7). H – N Same as in (A) – (G) but showing frequencies of each cell population for female MaFIA mice at 12 weeks after surgery for Vehicle (yellow, n = 4) or AP20187 (purple, n = 6) treated mice. Statistical analysis by Mann-Whitney test. Error bars show mean +/- 95% CI. P values stated on graphs; significant if p < 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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