Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage

Table 2 Macrophage marker genes regulated in the DRG after AP20187 treatment

	Gene	DMM AP vs. DMM veh DRG Bulk RNAseq + 8 weeks (log2(fc))
M2-like	Fcrls	1.35 (p = 0.03)
	Cd163	1.11 (p = 0.01)
	Mrc1	1.44 (p = 0.001)
M1-like	Ccr2	−2.64 (p = 0.000004)
M1-like	H2-Aa	−1.87 (p = 0.001)

ISSN: 1478-6362