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Table 2 Comparison of the histopathological characteristics between different subgroups of patients

From: Development of differential diagnostic models for distinguishing between limb-girdle muscular dystrophy and idiopathic inflammatory myopathy

 

IIM (n = 71)

LGMDR2 (n = 24)

LGMDR1 (n = 21)

p1

value

p2 value

p3 value

Score

Myonecrosis

0

1

2

0

1

2

0

1

2

0.159

0.318

0.652

2, 2.8%

34, 47.9%

35, 49.3%

2, 8.3%

15, 62.5%

7, 29.2%

3, 14.3%

14, 66.7%

4, 19.0%

   

Fibers with internalized nuclei > 3%

21, 29.6%

19, 79.2%

15, 71.4%

< 0.0001

0.0008

0.730

Hypertrophic/splitting fibers

14, 19.7%

8, 33.3%

14, 66.7%

0.262

< 0.0001

0.038

Ragged red fibers

6, 8.5%

7, 29.2%

5, 23.8%

0.017

0.117

0.746

Whorled/

ring fibers

7, 9.9%

6, 25.0%

9, 42.9%

0.085

0.001

0.226

Eosinophils infiltration

5, 7.0%

0

3, 14.3%

0.325

0.377

0.094

Score

0

1

2

0

1

2

0

1

2

   

Endomysial CD3 infiltration

5, 7.0%

29, 40.8%

37, 52.1%

0

18, 75.0%

6, 25.0%

1, 4.8%

11, 52.4%

9, 42.9%

0.012

0.637

0.212

Perimysial CD3 infiltration

17, 23.9%

34, 47.9%

20, 28.2%

12, 50.0%

12, 50.0%

0,0%

4, 19.0%

14, 66.7%

3, 14.3%

0.005

0.284

0.030

Endomysial CD8 infiltration

15, 21.1%

34, 47.9%

22, 31.0%

8, 33.3%

14, 58.3%

2, 8.3%

4, 19.0%

12, 57.1%

5, 23.8%

0.077

0.742

0.275

Perimysial CD8 infiltration

37, 52.1%

27, 38.0%

7, 9.9%

18, 75.0%

6, 25.0%

0

9, 42.3%

12, 57.1%

0

0.088

0.154

0.037

Endomysial CD20 infiltration

66, 93.0%

4, 5.6%

1, 1.4%

23, 95.8%

1, 4.2%

0

20, 95.2%

1, 4.8%

0

0.808

0.849

> 0.999

Perimysial CD20 infiltration

65, 91.5%

5, 7.0%

1, 1.4%

24,100.0%

0

0

20, 95.2%

1, 4.8%

0

0.339

0.799

0.467

Endomysial CD68 infiltration

0

15, 21.1%

56, 78.9%

1, 4.2%

5, 20.8%

18, 75.0%

0

4, 19.0%

17, 81.0%

0.224

> 0.999

0.624

Perimysial CD68 infiltration

1, 1.4%

39, 54.9%

31, 43.7%

2, 8.3%

9, 37.5%

13, 54.2%

0

11, 52.4%

10, 47.6%

0.121

0.830

0.301

Positive MHC-I expression

65, 91.5%

19, 79.2%

9, 42.9%

0.138

< 0.0001

0.016

Diffuse MHC-I expression

35, 49.3%

0

3, 14.3%

< 0.0001

0.005

0.094

MAC deposition on sarcolemma

61, 85.9%

22, 91.7%

13, 61.9%

0.724

0.026

0.029

MAC deposition on capillaries

4, 5.6%

0

0

0.569

0.570

—

  1. Abbreviation : IIM: idiopathic inflammatory myopathy; LGMD: limb-girdle muscular dystrophy; MHC-I: major histocompatibility complex class-I; MAC: membrane attack complex; p1 value: IIM vs. LGMDR2, p2 value: IIM vs. LGMDR1, p3 value: LGMDR1 vs. LGMDR2
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Arthritis Research & Therapy

ISSN: 1478-6362

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