Table 4 Clinical features of EGPA patients with severe gastrointestinal lesions
Characteristics | With severe GI lesions, n = 22 | Without severe GI lesions, n = 30 | P value |
|---|---|---|---|
Demographics | |||
Age, years, mean ± SD | 46.5 ± 14.5 | 47.4 ± 14.8 | 0.813 |
Gender, male/female, number | 15/7 | 17/13 | 0.399 |
Duration from allergy to EGPA diagnosis (month), median (IQR) | 5 (0, 71) | 31 (5, 120) | 0.213 |
Duration from initial symptoms to EGPA diagnosis (month), median (IQR) | 4 (1, 18) | 18 (7, 60) | 0.028 |
Laboratory examinations | |||
Eosinophil count (x109/L), median (IQR) | 5.5 (2.1, 9.3) | 3.3 (1.7, 5.8) | 0.226 |
Eosinophil ratio (%), median (IQR) | 41.0 (20.8, 51.4) | 29.8 (20.5, 44.1) | 0.384 |
ESR, mm/1 h, median (IQR) | 44 (29, 66) | 29 (6, 45) | 0.056 |
CRP, mg/L, median (IQR) | 39.5 (10.6, 87.2) | 6.8 (2.0, 40.7) | 0.053 |
RF, IU/mL, median (IQR) | 21 (10, 196) | 11 (6, 42) | 0.544 |
MPO-ANCA, n (%) | 6 (27.3) | 3 (10.0) | 0.144 |
PR3-ANCA, n (%) | 3 (13.6) | 0 (0) | 0.070 |
Eosinophilic tissue infiltration, n (%) | 13 (81.3) | 21 (84.0) | > 0.999 |
Biopsy-proven vasculitis | 4 (21.1) | 7 (25.9) | 0.976 |
Clinical manifestations, n (%) | |||
Fever | 14 (63.6) | 15 (50.0) | 0.328 |
Weight loss | 14 (63.6) | 15 (50.0) | 0.328 |
Arthritis | 4 (18.2) | 6 (20.0) | > 0.999 |
Myalgia | 4 (18.2) | 10 (33.3) | 0.224 |
Allergic rhinitis | 8 (36.4) | 14 (46.7) | 0.458 |
Severe asthma | 10 (45.5) | 23 (76.7) | 0.021 |
Renal involvement | 11 (50.0) | 8 (26.7) | 0.084 |
Increased serum creatinine | 5 (22.7) | 3 (10.0) | 0.260 |
Abnormal urine test | 10 (45.5) | 8 (26.7) | 0.159 |
Skin involvement | 12 (54.5) | 18 (60.0) | 0.694 |
PNS involvement | 13 (59.1) | 14 (46.7) | 0.376 |
CNS involvement | 9 (40.9) | 5 (16.7) | 0.052 |
Cardiac involvement | 8 (36.4) | 11 (36.7) | 0.982 |
ENT involvement | 10 (45.5) | 24 (80.0) | 0.010 |
Clinical score | |||
BVAS, mean ± SD | 25 ± 11 | 17 ± 7 | 0.002 |
BVAS-GI, ‡ mean ± SD | 20 ± 10 | 14 ± 7 | 0.013 |
FFS ⩾ 2, n (%) | 13 (59.1) | 4 (13.3) | 0.001 |
Treatment, n (%) | |||
GC pulse | 11 (50.0) | 5 (16.7) | 0.010 |
Intravenous CYC | 17 (77.3) | 18 (60.0) | 0.190 |
IVIG | 6 (27.3) | 3 (10.0) | 0.144 |