Fig. 5

Clinical relevance analysis of exosome miR-199a-5p, serum MMP2 and TIMP2. A-D Correlation analysis of exosome miR-199a-5p and cardiovascular and peripheral vascular damage index, disease duration, ESR and CRP levels respectively. The cardiovascular and peripheral vascular damage index refers to the score of vascular-related events including cardiovascular and peripheral vascular disease in VDI. E Levels of exosome miR-199a-5p between active and stable groups showed no significant difference. F Levels of serum MMP2 in TAK patients were significantly lower than that in healthy controls. G Correlation analysis of serum MMP2 and cardiovascular and peripheral vascular damage index. H Levels of serum TIMP2 between TAK patients and healthy controls showed no significant difference. I The ratio of MMP2/TIM2 level between TAK patients and healthy controls showed no significant difference. All correlation analyses mentioned above were assessed using Spearman’s correlation analysis. Vasculitis Damage Index: VDI; TAK: Takayasu’s arteritis; HC: healthy control; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; MMP2: matrix metalloproteinase-2; TIMP2: tissue inhibitor of metalloproteinases-2. ns: P > 0.05; **P ≤ 0.01