Table 1 General demographic data of patients with anti-MDA5 antibody + DM- ILD
Variable | Survival N = 17 | Non-survival N = 23 | p-value | |
|---|---|---|---|---|
Gender | 0.747 | |||
Male | 6 (35%) | 10 (43%) | ||
Female | 11 (65%) | 13 (57%) | ||
Age | 48 ± 14 | 56 ± 10 | 0.040 | |
Smoker | 1 (5.9%) | 3 (13%) | 0.624 | |
Fever | 4 (24%) | 10 (43%) | 0.315 | |
Cough | 7 (41%) | 15 (65%) | 0.200 | |
Dyspnea | 5 (29%) | 14 (61%) | 0.062 | |
Clinical features | Pulmonary interstitial changes | 3 (18%) | 11 (48%) | 0.092 |
Pulmonary interstitial changes with rash | 6 (35%) | 4 (17%) | 0.274 | |
Pulmonary interstitial changes with Joint & Muscle | 1 (5.9%) | 1 (4.3%) | > 0.999 | |
Pulmonary interstitial changes with Rash、Joint & Muscle | 7 (41%) | 7 (30%) | 0.521 | |
Rash with itching | 13 (76%) | 13 (57%) | 0.315 | |
Joint pain | 5 (29%) | 7 (30%) | > 0.999 | |
P/F | 350 (310, 399) | 247 (185, 300) | 0.006 | |
Ro-52_antibody | 12 (71%) | 12 (52%) | 0.332 | |
RPILD (n,%) | 7 (41%) | 21(91%) | 0.001 | |
DAD | 1 (5.9%) | 9 (39%) | 0.026 | |
NSIP | 1 (5.9%) | 5 (22%) | 0.216 | |
OP | 10 (59%) | 14 (61%) | > 0.999 | |
Mediastinal emphysema | 1 (5.9%) | 0 (0%) | 0.425 | |
Grid shadow | 14 (82%) | 17 (74%) | 0.707 | |
Extent of lung lesions | 0.016 | |||
1 | 7 (41%) | 5 (22%) | ||
2 | 10 (59%) | 8 (35%) | ||
≥ 3 | 0 (0%) | 10 (44%) | ||
Treatment | < 0.001 | |||
GCs | 0 (0%) | 9 (39%) | ||
GCs combined with one immunosuppressant | 1 (5.9%) | 7 (30%) | ||
GCs combined with two immunosuppressants | 16 (94%) | 7 (30%) | ||
WBC | 4.77 ± 2.79 | 5.61 ± 2.40 | 0.325 | |
Hb | 121 ± 15 | 124 ± 23 | 0.604 | |
N | 3.50 ± 2.74 | 4.32 ± 2.18 | 0.317 | |
L | 0.90 ± 0.36 | 0.79 ± 0.28 | 0.293 | |
D-Dimer | 1,08(67, 1,68) | 1,55(83, 2,22) | 0.317 | |
IgE | 102 (35, 133) | 72 (28, 136) | 0.476 | |
IgG | 15.8 ± 3.2 | 15.1 ± 4.8 | 0.628 | |
C3 | 0.91 ± 0.21 | 1.04 ± 0.24 | 0.099 | |
ALT | 25 (18, 55) | 43 (30, 61) | 0.238 | |
AST | 39 (32, 59) | 57 (45, 99) | 0.216 | |
LDH | 328 ± 101 | 433 ± 117 | 0.005 | |
CK | 81 (50, 133) | 117 (54, 207) | 0.159 | |
GLU | 32 (25, 48) | 46 (27, 92) | 0.029 | |
AKP | 70 (58, 81) | 75 (59, 99) | 0.142 | |
ALB | 32.6 ± 5.2 | 29.9 ± 3.8 | 0.078 | |
ESR | 33 ± 21 | 44 ± 24 | 0.165 | |
PCT | 0.05 (0.05, 0.10) | 0.08 (0.05, 0.19) | 0.082 | |
Cre | 39 ± 11 | 45 ± 13 | 0.193 | |
CEA | 2 (2, 3) | 8 (4, 13) | 0.002 | |
Ferritin | 569 (475, 766) | 946 (673, 1362) | 0.032 | |
CRP | 3 (3, 9) | 13 (4, 49) | 0.003 | |
Follow-up | 641 (343, 787) | 31 (14, 63) | < 0.001 | |