Fig. 2

Unsupervised consensus clustering. (A) Consensus heatmap of the three subgroups. The subgroups were designated C1(n = 40), C2(n = 70), and C3(n = 58). The consensus value ranges from 0 (never clustered together) to 1 (always clustered together) marked by blue and red colors. (B) Determination of the optimum number K of clustering. The cumulative distribution function (CDF), adjusted P value, entropy, and proportion of ambiguous clustering (PAC) were used to determine the optimum K of clustering. See the interpretation in the Methods. (C) t-Distributed stochastic neighbor embedding (t-SNE) analysis of the clustered gene expression profiles