Fig. 5

Differential changes in molecular signatures by treatment response to IL-1 inhibitor. (A) Expression values of the top 5 leading-edge genes in IL-1 signaling pathways by GSEA. (B) Correlation between enrichment score of NF-κB signaling pathway and ACR response. The correlation coefficient and P value were obtained by Pearson’s method. (C) Correlation between the two most significant modules (M13.16 and M15.113) in blood transcriptome modular repertoire analysis and ACR response. The correlation coefficient and P value were obtained by Pearson’s method. (D) Temporal changes of the key featured signaling pathways between baseline and day 3 after treatment. A paired t-test determined the P-value. (E) Proportion of ACR response across the three subgroups. The adapted JIA ACR 30, JIA ACR 50, JIA ACR 70, JIA ACR 90, and JIA ACR 100 responses were defined as improvements of at least 30%, 50%, 70%, 90%, and 100%, respectively