Fig. 6

Identification of key influential genes with therapeutic potentials. (A) The enriched compound classes that agree or oppose the C1 gene expression signatures and their enrichment score. A negative normalized enrichment score indicates that a compound could counteract a given gene expression profiles. Asterisks indicate statistical significance (P value < 0.05). (B) The integrated value of influence, spreading, and hubness of the genes in the C1 molecular network of disease module. The spreading score reflects the ability of the node to propagate information and the hubness score measures the impact of each node within its domain. The integrated value of influence is the synergistic product of hubness and spreading values. (C) Expression values of the IL1B, IL1R1, IL1R2, GSK3B, and MAPK14 in the immune cell subsets. The data was sourced from the Human Protein Atlas (https://www.proteinatlas.org/)