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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Establishment of an ex vivo cartilage damage model by combined collagenase treatment and mechanical loading

Fig. 5

Cartilage surface cells did not survive under 20–40% compression of cartilage thickness and 25 degrees shear. While there were reduced numbers of LDH positive viable cells, TUNEL staining was negative. (A) LDH/EthD staining, TUNEL staining, SO-FG, IHC-stained with anti-COL2A1, anti-ACAN, and anti-neo-epitopes of aggrecan (n = 3). (B) Quantification of cell viability, COL2A1, ACAN, neo-epitope of aggrecan under loading conditions (20–40% compression and 25 degrees shear). Scale bar = 100 μm

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Arthritis Research & Therapy

ISSN: 1478-6362

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