Fig. 2
From: Enhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies
Figure legend. Marked systemic oxidative stress response is associated with decreased serum myoglobin levels in most myositis patients. a Graph showing cumulative generation of fluorescent (FL) product in CBA assay showing stratification of myositis patients into those with signs of high (≥ 0.75 quartile [Q], n = 10) or low/moderate (< 0.75 Q, n = 28) systemic stress response. b FL curves of real-time CBA assay in individual myositis patients stratified as in “a”. Bold lines indicate median values with shaded areas marking 0.25 to 0.75 Q ranges. For clarity, axes were truncated at 1600 FLU/mL and 10 h. c Serum myoglobin concentration in myositis patients with high or low/moderate serum protein hydroperoxides (HP) formation. Abbreviations: UL, an upper limit of the reference range. *p < 0.05 (Mann–Whitney test). d The highest reported (disease history) serum creatine kinase activity in the indicated subgroups of myositis. e Scatter plot of the correlation between cumulative FL product generation (FLU/mLxmin) and serum myoglobin levels (µg/L) in myositis patients. Abbreviations: rS – Spearman coefficient