Table 2 Relative TLR mRNA expression according to SLE subgroup and healthy control

A) SLE patients vs. healthy controls

Gene

Mean (95% CI)

P value

Controls

SLE

TLR1

0.0482 (0.005‒0.107)

0.053 (0.006‒0.176)

0.599

TLR2

0.039 (4.75 × 10^− 5‒0.208)

0.040 (1.7 × 10^− 4‒0.213)

0.590

TLR3

0.002 (2.51 × 10^− 5‒0.017)

0.0009 (2.46 × 10^− 5‒0.013)

0.122

TLR4

0.044 (0.008‒0.118)

0.081 (0.011‒0.503)

0.012*

TLR5

0.021 (3.94 × 10^− 5‒0.76)

0.020 (2.81 × 10^− 5‒0.103)

0.976

TLR6

0.03 (6.4 × 10^− 4‒0.117)

0.041 (0.004‒0.230)

0.323

TLR7

0.014 (1.56 × 10^− 4 ‒0.039)

0.019 (6.63 × 10^− 5‒0.104)

0.655

TLR8

0.043 (0.004‒0.190)

0.047 (2.42 × 10^− 4‒0.241)

0.682

TLR9

0.010 (2.5 × 10^− 5‒0.022)

0.012 (4.69 × 10^− 5‒0.073)

0.408

TLR10

0.009 (5.0 × 10^− 4‒0.022)

0.006 (2.71 × 10^− 5‒0.430)

0.0007*

B) Active LN-SLE vs. Inactive LN-SLE vs. No LN-SLE Patients

Gene

Mean (95% CI)

P value

Active LN-SLE

Inactive LN-SLE

No LN-SLE

Active vs. Inactive LN-SLE

Active vs. No LN SLE

Inactive vs. No LN SLE

TLR1

0.061 (0.017‒0.094)

0.044 (0.007‒0.102)

0.051 (0.006‒0.175)

0.087

0.194

0.377

TLR2

0.078 (0.007‒0.213)

0.041(0.002‒0.088)

0.030 (1.6 × 10^− 4‒0.117)

0.291

0.009*

0.066

TLR3

5.7 × 10^− 4(5.7 × 10^− 5‒0.003)

6.4 × 10^− 4(2.9 × 10^− 5‒0.002)

0.001 (2.5 × 10^− 5‒0.014)

0.545

0.567

0.603

TLR4

0.076 (0.033‒0.147)

0.06 (0.011‒0.261)

0.079 (0.015‒0.325)

0.077

0.269

0.544

TLR5

0.035 (1.2 × 10^− 4‒0.103)

0.02(2.8 × 10^− 5‒0.070)

0.017 (4.7 × 10^− 5‒0.102)

0.202

0.037*

0.883

TLR6

0.039 (0.015‒0.097)

0.055 (0.014‒0.23)

0.036 (0.004‒0.168)

0.936

0.134

0.171

TLR7

0.017 (0.006‒0.039)

0.022(0.005‒0.06)

0.0188 (6.6 × 10^− 5‒0.241)

0.599

0.344

0.383

TLR8

0.050 (0.008‒0.096)

0.051 (0.012‒0.714)

0.041 (2.4 × 10^− 4‒0.039)

0.687

0.101

0.136

TLR9

0.017 (6.5 × 10^− 5‒0.061)

0.017 (0.003‒0.073)

0.009 (4.7 × 10^− 5‒0.39)

0.676

0.142

0.019*

TLR10

0.007 (6.5 × 10^− 5‒0.017)

0.005 (2.5 × 10^− 4‒0.02)

0.006 (2.7 × 10^− 5‒0.061)

0.467

0.273

0.777

C) CNS-SLE vs. No CNS-SLE patients

Gene

Mean (95% CI)

P value

CNS-SLE

No CNS-SLE

TLR1

0.088 (0.038‒0.150)

0.048 (0.006‒0.176)

0.0199*

TLR2

0.020 (4.0 × 10^− 4‒0.083)

0.041 (1.6 × 10^− 4‒0.213)

0.0986

TLR3

3.36 × 10^− 4 (7.9 × 10^− 5‒5.9 × 10^− 4)

0.001 (2.46 × 10^− 5‒0.014)

0.8946

TLR4

0.173 (0.084‒0.295)

0.066 (0.011‒0.325)

0.0003*

TLR5

0.008 (0.002‒0.014)

0.022 (2.81 × 10^− 5‒0.104)

0.3839

TLR6

0.087 (0.025‒0.168)

0.036 (0.004‒0.23)

0.0070*

TLR7

0.048 (1.96 × 10^− 4‒0.104)

0.017 (6.63 × 10^− 5‒0.094)

0.1534

TLR8

0.096 (0.02‒0.242)

0.04 (2.4 × 10^− 4‒0.172)

0.1437

TLR9

0.009 (3.91 × 10^− 4 ‒0.039)

0.012 (4.69 × 10^− 5‒0.073)

0.2179

TLR10

0.017 (5.93 × 10^− 4‒0.062)

0.005 (2.71 × 10^− 5‒0.02)

0.3102