Fig. 1

Partial medial meniscectomy causes loss of articular cartilage and mBSA injection causes joint swelling. A Schematic showing experimental time course for the partial medial meniscectomy model of osteoarthritis. B The average OARSI score to measure cartilage degradation for the medial and lateral compartments of the knee joint. Note that a minimum OARSI score of 0.5 was given to all samples because there was a lack of red staining in the superficial cartilage in all sections. C&D Example images of Safranin O & fast green-stained knee joint sections in PMX (C) and Sham (D) mice at 13–15 weeks post-surgery. Scale bar = 200 µm. E) Schematic showing experimental time course for the antigen induced arthritis model of rheumatoid arthritis. F) Ratio of the ipsilateral to contralateral knee size in AIA mice. Each point represents data from an individual animal. PMX: n = 9–10 mice/group AIA: n = 11 mice/group. males = closed circles, females = open circles. PMX data: *** p < 0.001 **** p < 0.0001, repeated measures ANOVA. AIA data: p < 0.0001, unpaired t-test