Fig. 4

Home cage analysis shows that activity was similar in partial medial meniscectomy and sham mice. A Schematic showing time course for the home cage analyzer experiments in OA mice. Home cage analysis was performed in cages that contained 4 mice with n = 2 PMX and n = 2 sham/cage. B-D Graphs showing the total distance travelled (B&C) and time spent mobile (D&E) at baseline and following surgery. Data in B) and D) are presented as mean ± SEM in 12 h intervals. Grey bars represent the dark phase. Data in C) and E) show the percentage change from baseline for the dark phase (19:00–07:00). F Graph showing the weight bearing ratio (right/left hind limb) over time. Data are presented as mean ± SEM. Home cage analysis assessed in n = 5 cages with n = 10 / group. Males = closed circles, females = open circles