Fig. 4

Left posterior insula connectivity to the brainstem and thalamus is associated with current pain. The panels above display the clusters in the brainstem and left thalamus whose connectivity with the left posterior insular cortex (LpIC) was associated with current overall body pain while controlling for age and sex. The panels below display the scatterplots (95% confidence intervals) with Pearson correlation coefficients (R) between the functional connectivity (Fisher z transformed r values) of the seeds and clusters with current overall body pain. The tables describe the peak voxel coordinates in MNI space (x, y, z), the cluster size, the degrees of freedom (df), the T statistics, and the p values after false discovery rate (FDR) correction for multiple comparisons of the general linear models (GLMs)